团队队伍

何玉娇

职称:副研究员

最高学历毕业院校及专业:中国科学院大学 药物化学专业

所属学科:药理学

电子邮件:heyujiao@cdu.edu.cn

个人简历

研究方向

代表性论著

教学科研项目及获奖

职称 副研究员 最高学历毕业院校及专业 中国科学院大学 药物化学专业
所属学科 药理学 电子邮箱 heyujiao@cdu.edu.cn
研究方向 肺部疾病新机制新靶点研究,及药物发现。 发表论文 1.Shishuang Yu1, Ke Liu1, Fengjiao Zhou1, Xiuli Yang, Junru Zhang, Kexin Yu, Yi Zhu, Ling Qin, Ting Peng*, Chuantao Zhang*, Yujiao He*. Nobiletin from Citrus reticulata Blanco alleviates pulmonary fibrosis through inhibiting the PI3K/AKT pathway and epithelial-mesenchymal transition. J Ethnopharmacol, 2025, 10:119965.<br>
2.Shishuang Yu1, Jufang Pu1, Ke Liu1, Cuifang He, Feifei Yang, Ke Chen, Xiuli Yang, Yi Zhu, Jun Jiang, Maocai Luo, Xiao Liu*, Chuantao Zhang*, Yujiao He*. Curcumin mediates oxidative stress to play an anti-fibrotic role, focusing on liver, renal, myocardial and pulmonary fibrosis. Front Pharmacol, 2025, 21;16:1636538.<br>
3.Dan Zhao1, Ting Peng1, Qing He, Sai Ruan, Jun Xie, Yiteng Zhao, Qin Lin, Binbing Zhang, Xiaohua Liu, Yujiao He*. A 3,4-diamino-substituted coumarin derivative as a TRBP inhibitor suppresses tumor growth in breast cancer by inducing cellular senescence, Am J Cancer Res, 2025, 15(10): 4553-4569.<br>
4.Hongbo Dong, Yuanwei You, Xiuli Yang, Ling Mei, Yufei Che, Na Wang, Ting Peng, Yujiao He*. Total synthesis and anti-inflammatory activity of tectoridin and related isoflavone glucosides. J Nat Prod. 2025, 88(1):94-102.<br>
5.Ting Peng, Bin Long, Xiuli Yang, Na Wang, Ximeng Wang, Yujiao He*, Hongbo Dong*. Total syntheses and anti-inflammatory studies of three natural coumarins: glycycoumarin, glycyrin, and 3-O-methylglycyrol. Molecules. 2024, 29(16):3942.<br>
6.Ting Peng#, Yujiao He#, Tao Wang#, Jialing Yu#, Xiaofang Ma#, Zongyuan Zhou, Yuwen Sheng, Lingyu Li, Huipan Peng, Sheng Li, Jiawei Zou, Yi Yuan, Yongyun Zhao, Hailong Shi, Fu Li, Wanli Liu, Kaifeng Hu*, Xiaoxia Lu*, Guolin Zhang*, and Fei Wang*. Discovery of a Novel Small-Molecule Inhibitor Disrupting TRBP–Dicer Interaction against Hepatocellular Carcinoma via the Modulation of microRNA Biogenesis. Journal of Medicinal Chemistry, 2022, 65(16), 11010-11033.<br>
7.Hongbo Dong, Min Wu, Ying Li, Lan Lu, Jialan Qin, Yujiao He,* and Zheng Shi*. Total syntheses and anti-inflammatory evaluations of pongamosides A–C, natural furanoflavonoid glucosides from fruit of Pongamia pinnata (L.) Pierre. Journal of Natural Products, 2022, 85(4), 1118-1127.<br>
8.Hongbo Dong, Min Wu, Weihong Du, Mingwei Shong, Yujiao He and Yuchi Wang (2022). First asymmetric total synthesis of Millpuline B. Synthetic Communications, 2022, 52(1), 79-84.<br>
9.Yujiao He, Maolin Huang, Chunyan Tang, Yan Yue, Xiao Liu, Zhebin Zheng, Hongbo Dong*, Deming Liu*. Dietary daidzein inhibits hepatitis C virus replication by decreasing microRNA-122 levels. Virus Research, 2021, 298, 198404.<br>
10.Hongbo Dong, Min Wu, Yingying Wang, Weihong Du, Yujiao He,* and Zheng Shi*. Total syntheses and anti-inflammatory activities of syringin and its natural analogues. Journal of Natural Products, 2021, 84(11), 2866-2874.<br>
11.Yujiao He, Xiao Liu, Maolin Huang, Zheng Wei, Mengyu Zhang, Mengtao He, Zhebin Zheng, Hongbo Dong*, Deming Liu*. (2021). Oleanolic acid inhibits the migration and invasion of hepatocellular carcinoma cells by promoting microRNA-122 expression. Die Pharmazie-An International Journal of Pharmaceutical Sciences, 2021, 76(9), 422-427.<br>
12.Guangya Xu, Min Wu, Zhongquan Yao, Hongbin Lou, Weihong Du, Mingwei Song, Yujiao He and Hongbo Dong. First total syntheses of four natural bioactive glucosides. Synthetic Communications, 2021, 51(8), 1266-1271.<br>
13.Hongbo Dong*, Weihong Du, Zhongquan Yao, Min Wu, Hongbing Luo, Yujiao He, Shenghua Cao. First total syntheses of two natural glycosides. Carbohydrate Research, 2021, 499, 108200.<br>
14.Yujiao He, Chunyan Zhou, Maolin Huang, Chunyan Tang, Xiao Liu, Yan Yue, Qingchun Diao*, Zhebin Zheng*, Deming Liu*. Glyoxalase system: A systematic review of its biological activity, related-diseases, screening methods and small molecule regulators. Biomedicine & Pharmacotherapy, 2020, 131, 110663.<br>
15.Orawan Wonganan, Yujiao He, Xiaofei Shen, Kanjana Wongkrajang, Apichart Suksamrarn, Guolin Zhang*, Fei Wang*. 6-Hydroxy-3-O-methyl-kaempferol 6-O-glucopyranoside potentiates the anti-proliferative effect of interferon α/β by promoting activation of the JAK/STAT signaling by inhibiting SOCS3 in hepatocellular carcinoma cells. Toxicology and Applied Pharmacology, 2017, 336, 31-39.<br>
16.Yujiao He, Junmei Huang, Ping Wang, Xiaofei Shen, Sheng Li, Lijuan Yang, Wanli Liu, Apichart Suksamrarn, Guolin Zhang*, Fei Wang*. Emodin potentiates the antiproliferative effect of interferon α/β by activation of JAK/STAT pathway signaling through inhibition of the 26S proteasome. Oncotarget, 2016, 7(4), 4664.<br>
17.Sheng Li#, Li-juan Yang#, Ping Wang, Yujiao He, Junmei Huang, Hanwei Liu, Xiaofei Shen and Fei Wang. Dietary apigenin potentiates the inhibitory effect of interferon-α on cancer cell viability through inhibition of 26S proteasome-mediated interferon receptor degradation. Food & nutrition research, 2016, 60(1), 31288.<br>
18.WeiHua Wang, Yin Nian, YuJiao He, Luo-Sheng Wan, Ni-Man Bao, Guo-Lei Zhu, Fei Wang, Ming-hua Qiu. New cycloartane triterpenes from the aerial parts of Cimicifuga heracleifolia. Tetrahedron, 2015, 71(42), 8018-8025.<br>
Zhengfu Tai#, Yuan Lin#, Yujiao He, Junmei Huang, Jiajia Guo, Lijuan Yang, Guolin Zhang*, FeiWang*. (2014). Luteolin sensitizes the antiproliferative effect of interferon α/β by activation of Janus kinase/signal transducer and activator of transcription pathway signaling through protein kinase A-mediated inhibition of protein tyrosine phosphatase SHP-2 in cancer cells. Cellular Signalling, 2014, 26(3), 619-628.<br>
教学科研成果 教学科研项目:<br>
1.国家自然科学基金青年科学基金项目(21702022),2018.01-2020.12,主持<br>
2.四川省自然科学基金面上项目(2024NSFSC0750),2024.01-2025.12,主持<br>
3.四川省抗感染药物创制工程研究中心开放课题(AAC2023004),2023.05-2024.05,主持<br>
4.四川省药物制剂及装备工程技术研究中心开放课题(ERCPEF21-01),2021.10-2022.10, 主持<br>
5.抗生素研究与再评价四川省重点实验室开放课题(ARRLKF19-11),2019.11-2021.12,主持<br>
6.四川省教育厅科研项目(18ZB0145),2018.01-2019.12,主持<br>
7.药食同源植物资源开发四川省高校重点实验室开放课题(10Y201711),2017.07-2019.12,主持<br>
8.抗生素研究与再评价四川省重点实验室开放课题(ARRLKF16-10),2016.10-2018.04,主持<br>
9.sunbet官网引进人才启动项目, 2016.10-2021.10,主持<br>
10.青年专家博士服务团专项,2025,主持<br><br>
参与教学获奖:<br>
1.教育部第四批“全国高校黄大年式教师团队”核心成员,2025年<br>
2.sunbet官网高等教育(研究生)教学成果奖特等奖,2025年<br>
3.sunbet官网高等教育(研究生)教学成果奖一等奖,2025年<br>
4.sunbet官网高等教育(本科)教学成果奖特等奖,2025年<br>
5.国际化视野下药学学科研究生创新人才培养探索与实践,教改项目,2025年,参与<br>
6.全国老员工生命科学竞赛国家三等奖,2025年,参与<br>
7.老员工创新训练计划国家级立项,2025年,参与<br>
8.四川省一流本科课程(药理学),2022,参与<br>
9.sunbet官网青年教师教学竞赛校级优秀奖,2021<br><br>
个人荣誉:<br>
1.2017年校级优秀员工<br>
2.2022年校级优秀员工<br>
3.2023入选学院“卓越人才培育计划”<br>
4.2023年教师党员示范(先锋)岗<br>
5.2023年校级优秀员工<br>
6.2024年度教职工师德师风考核优秀人员<br>
7.2025年校级优秀员工<br>

何玉娇,博士研究生,副研究员,硕士生导师,联合培养博士生导师。

兼职情况国家自然科学基金四川省自然科学基金、重庆市自然科学基金评审专家,中国药学会会员,四川省科技青年联合会会员,Cellular Signalling、Biomedicine & Pharmacotherapy等国际学术期刊,《中药药理与临床》等核心期刊审稿人。

最高学历毕业院校及专业:2016年7月毕业于中国科学院大学药物化学专业(药理学方向)

所属学科:药理学

电子邮件:heyujiao@cdu.edu.cn





肺部疾病新机制新靶点研究,及药物发现。

1.Shishuang Yu1, Ke Liu1, Fengjiao Zhou1, Xiuli Yang, Junru Zhang, Kexin Yu, Yi Zhu, Ling Qin, Ting Peng*, Chuantao Zhang*, Yujiao He*. Nobiletin from Citrus reticulata Blanco alleviates pulmonary fibrosis through inhibiting the PI3K/AKT pathway and epithelial-mesenchymal transition. J Ethnopharmacol, 2025, 10:119965.
2.Shishuang Yu1, Jufang Pu1, Ke Liu1, Cuifang He, Feifei Yang, Ke Chen, Xiuli Yang, Yi Zhu, Jun Jiang, Maocai Luo, Xiao Liu*, Chuantao Zhang*, Yujiao He*. Curcumin mediates oxidative stress to play an anti-fibrotic role, focusing on liver, renal, myocardial and pulmonary fibrosis. Front Pharmacol, 2025, 21;16:1636538.
3.Dan Zhao1, Ting Peng1, Qing He, Sai Ruan, Jun Xie, Yiteng Zhao, Qin Lin, Binbing Zhang, Xiaohua Liu, Yujiao He*. A 3,4-diamino-substituted coumarin derivative as a TRBP inhibitor suppresses tumor growth in breast cancer by inducing cellular senescence, Am J Cancer Res, 2025, 15(10): 4553-4569.
4.Hongbo Dong, Yuanwei You, Xiuli Yang, Ling Mei, Yufei Che, Na Wang, Ting Peng, Yujiao He*. Total synthesis and anti-inflammatory activity of tectoridin and related isoflavone glucosides. J Nat Prod. 2025, 88(1):94-102.
5.Ting Peng, Bin Long, Xiuli Yang, Na Wang, Ximeng Wang, Yujiao He*, Hongbo Dong*. Total syntheses and anti-inflammatory studies of three natural coumarins: glycycoumarin, glycyrin, and 3-O-methylglycyrol. Molecules. 2024, 29(16):3942.
6.Ting Peng#, Yujiao He#, Tao Wang#, Jialing Yu#, Xiaofang Ma#, Zongyuan Zhou, Yuwen Sheng, Lingyu Li, Huipan Peng, Sheng Li, Jiawei Zou, Yi Yuan, Yongyun Zhao, Hailong Shi, Fu Li, Wanli Liu, Kaifeng Hu*, Xiaoxia Lu*, Guolin Zhang*, and Fei Wang*. Discovery of a Novel Small-Molecule Inhibitor Disrupting TRBP–Dicer Interaction against Hepatocellular Carcinoma via the Modulation of microRNA Biogenesis. Journal of Medicinal Chemistry, 2022, 65(16), 11010-11033.
7.Hongbo Dong, Min Wu, Ying Li, Lan Lu, Jialan Qin, Yujiao He,* and Zheng Shi*. Total syntheses and anti-inflammatory evaluations of pongamosides A–C, natural furanoflavonoid glucosides from fruit of Pongamia pinnata (L.) Pierre. Journal of Natural Products, 2022, 85(4), 1118-1127.
8.Hongbo Dong, Min Wu, Weihong Du, Mingwei Shong, Yujiao He and Yuchi Wang (2022). First asymmetric total synthesis of Millpuline B. Synthetic Communications, 2022, 52(1), 79-84.
9.Yujiao He, Maolin Huang, Chunyan Tang, Yan Yue, Xiao Liu, Zhebin Zheng, Hongbo Dong*, Deming Liu*. Dietary daidzein inhibits hepatitis C virus replication by decreasing microRNA-122 levels. Virus Research, 2021, 298, 198404.
10.Hongbo Dong, Min Wu, Yingying Wang, Weihong Du, Yujiao He,* and Zheng Shi*. Total syntheses and anti-inflammatory activities of syringin and its natural analogues. Journal of Natural Products, 2021, 84(11), 2866-2874.
11.Yujiao He, Xiao Liu, Maolin Huang, Zheng Wei, Mengyu Zhang, Mengtao He, Zhebin Zheng, Hongbo Dong*, Deming Liu*. (2021). Oleanolic acid inhibits the migration and invasion of hepatocellular carcinoma cells by promoting microRNA-122 expression. Die Pharmazie-An International Journal of Pharmaceutical Sciences, 2021, 76(9), 422-427.
12.Guangya Xu, Min Wu, Zhongquan Yao, Hongbin Lou, Weihong Du, Mingwei Song, Yujiao He and Hongbo Dong. First total syntheses of four natural bioactive glucosides. Synthetic Communications, 2021, 51(8), 1266-1271.
13.Hongbo Dong*, Weihong Du, Zhongquan Yao, Min Wu, Hongbing Luo, Yujiao He, Shenghua Cao. First total syntheses of two natural glycosides. Carbohydrate Research, 2021, 499, 108200.
14.Yujiao He, Chunyan Zhou, Maolin Huang, Chunyan Tang, Xiao Liu, Yan Yue, Qingchun Diao*, Zhebin Zheng*, Deming Liu*. Glyoxalase system: A systematic review of its biological activity, related-diseases, screening methods and small molecule regulators. Biomedicine & Pharmacotherapy, 2020, 131, 110663.
15.Orawan Wonganan, Yujiao He, Xiaofei Shen, Kanjana Wongkrajang, Apichart Suksamrarn, Guolin Zhang*, Fei Wang*. 6-Hydroxy-3-O-methyl-kaempferol 6-O-glucopyranoside potentiates the anti-proliferative effect of interferon α/β by promoting activation of the JAK/STAT signaling by inhibiting SOCS3 in hepatocellular carcinoma cells. Toxicology and Applied Pharmacology, 2017, 336, 31-39.
16.Yujiao He, Junmei Huang, Ping Wang, Xiaofei Shen, Sheng Li, Lijuan Yang, Wanli Liu, Apichart Suksamrarn, Guolin Zhang*, Fei Wang*. Emodin potentiates the antiproliferative effect of interferon α/β by activation of JAK/STAT pathway signaling through inhibition of the 26S proteasome. Oncotarget, 2016, 7(4), 4664.
17.Sheng Li#, Li-juan Yang#, Ping Wang, Yujiao He, Junmei Huang, Hanwei Liu, Xiaofei Shen and Fei Wang. Dietary apigenin potentiates the inhibitory effect of interferon-α on cancer cell viability through inhibition of 26S proteasome-mediated interferon receptor degradation. Food & nutrition research, 2016, 60(1), 31288.
18.WeiHua Wang, Yin Nian, YuJiao He, Luo-Sheng Wan, Ni-Man Bao, Guo-Lei Zhu, Fei Wang, Ming-hua Qiu. New cycloartane triterpenes from the aerial parts of Cimicifuga heracleifolia. Tetrahedron, 2015, 71(42), 8018-8025.
Zhengfu Tai#, Yuan Lin#, Yujiao He, Junmei Huang, Jiajia Guo, Lijuan Yang, Guolin Zhang*, FeiWang*. (2014). Luteolin sensitizes the antiproliferative effect of interferon α/β by activation of Janus kinase/signal transducer and activator of transcription pathway signaling through protein kinase A-mediated inhibition of protein tyrosine phosphatase SHP-2 in cancer cells. Cellular Signalling, 2014, 26(3), 619-628.

教学科研项目:
1.国家自然科学基金青年科学基金项目(21702022),2018.01-2020.12,主持
2.四川省自然科学基金面上项目(2024NSFSC0750),2024.01-2025.12,主持
3.四川省抗感染药物创制工程研究中心开放课题(AAC2023004),2023.05-2024.05,主持
4.四川省药物制剂及装备工程技术研究中心开放课题(ERCPEF21-01),2021.10-2022.10, 主持
5.抗生素研究与再评价四川省重点实验室开放课题(ARRLKF19-11),2019.11-2021.12,主持
6.四川省教育厅科研项目(18ZB0145),2018.01-2019.12,主持
7.药食同源植物资源开发四川省高校重点实验室开放课题(10Y201711),2017.07-2019.12,主持
8.抗生素研究与再评价四川省重点实验室开放课题(ARRLKF16-10),2016.10-2018.04,主持
9.sunbet官网引进人才启动项目, 2016.10-2021.10,主持
10.青年专家博士服务团专项,2025,主持

参与教学获奖:
1.教育部第四批“全国高校黄大年式教师团队”核心成员,2025年
2.sunbet官网高等教育(研究生)教学成果奖特等奖,2025年
3.sunbet官网高等教育(研究生)教学成果奖一等奖,2025年
4.sunbet官网高等教育(本科)教学成果奖特等奖,2025年
5.国际化视野下药学学科研究生创新人才培养探索与实践,教改项目,2025年,参与
6.全国老员工生命科学竞赛国家三等奖,2025年,参与
7.老员工创新训练计划国家级立项,2025年,参与
8.四川省一流本科课程(药理学),2022,参与
9.sunbet官网青年教师教学竞赛校级优秀奖,2021

个人荣誉:
1.2017年校级优秀员工
2.2022年校级优秀员工
3.2023入选学院“卓越人才培育计划”
4.2023年教师党员示范(先锋)岗
5.2023年校级优秀员工
6.2024年度教职工师德师风考核优秀人员
7.2025年校级优秀员工